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In this issue of The Business of Government magazine, we survey the intersection where leadership, complex challenges, and the need for transformation meet. Whether it’s in the response to the global financial crisis, the national deficit, or the myriad of other pressing issues facing us, uncertainty seems boundless while constraints on resources are very real. It is within this context that we’ve assembled a varied group of government executives and thought leaders who are focusing on these problems and working to mitigate their effects. They offer their insights, lessons learned, and recommendations on these topics. It’s about connecting research to practice—crafting smart approaches that tame immediate demands without losing sight of the iterative nature of problem solving. This goes to the core of the Center’s mission: linking theory to practice as a way of shaping the business of government.